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Dalteparin dosing of cipro



Coadministration with serotonergic drugs

  • Coadministration with monoamine oxidase inhibitors (MAOIs)
  • Concomitant MAOIs administration within 14 days before initiating venlafaxine or within 7 days after discontinuing venlafaxine
  • Initiation of venlafaxine in patient being treated with linezolid or IV methylene blue


Risk of mydriasis; may trigger angle closure attack in patients with angle closure glaucoma with anatomically narrow angles without a patent iridectomy

Use caution in bipolar mania, history of seizures, and cardiovascular disease

May precipitate mania or hypomania episodes in patients with bipolar disorder; avoid monotherapy in bipolar disorder; screen patients presenting with depressive symptoms for bipolar disorder

Use caution in hepatic or renal impairment

Neonates exposed to serotonin-norepinephrine reuptake inhibitors (SNRIs) or selective serotonin reuptake inhibitors (SSRIs) late in 3rd trimester of pregnancy have developed complications necessitating prolonged hospitalization, respiratory support, and tube feeding

Clinical worsening and suicidal ideation may occur despite medication in adolescents and young adults (18-24 years)

When discontinuing, taper dosage to avoid flulike symptoms

May cause increase in nervousness, anxiety, or insomnia

May impair ability to operate heavy machinery; depresses CNS

Bone fractures reported with antidepressant therapy; consider possibility if patient experiences bone pain

May cause significant increase in serum cholesterol

Dose-dependent anorectic effects and weight loss reported in children and adult patients

Dose-related increase in systolic and diastolic pressure reported

Eosinophilic pneumonia and interstitial lung disease reported

SAIDH and hyponatremia reported SSRIs

Potentially life-threatening serotonin syndrome with SSRIs and SNRIs when used in combination with other serotonergic agents including TCAs, buspirone tryptophan, dalteparin dosing of cipro fentanyl, tramadol, lithium, tryptophan, buspirone, amphetamines, St. John’s Wort, and triptans; symptoms include tremor, myoclonus, diaphoresis, nausea, vomiting, flushing, dizziness, hyperthermia with features resembling neuroleptic malignant syndrome, seizures, rigidity, autonomic instability with possible rapid fluctuations of vital signs, and mental status changes that include extreme agitation progressing to delirium and coma

Venlafaxine in patient being treated with linezolid or IV methylene blue increases risk of serotonin syndrome; if linezolid or IV methylene blue must be administered, discontinue venlafaxine immediately and monitor for central nervous system (CNS) toxicity; therapy may be resumed 24 hours after last linezolid or methylene blue dose or after 2 weeks of monitoring, whichever comes first

SSRIs and SNRIs may impair platelet aggregation and increase the risk of bleeding events, ranging from ecchymoses, hematomas, epistaxis, petechiae, and GI hemorrhage to life-threatening hemorrhage; concomitant use of aspirin, NSAIDs, warfarin, other anticoagulants, or other drugs known to affect platelet function may add to this risk

Control hypertension before initiating treatment; monitor blood pressure regularly during treatment

Risks of sustained hypertension, hyponatremia, and impeded height and weight in children

Drug-laboratory test interactions: False-positive urine immunoassay screening tests for phencyclidine (PCP) and amphetamine have been observed during venlafaxine therapy because of lack of specificity of the screening tests

May cause or exacerbate sexual dysfunction


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